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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
29.7
Human Site:
Y523
Identified Species:
50.26
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
Y523
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
L
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
M391
Y
K
N
L
Q
L
F
M
E
S
K
G
P
R
D
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
Y525
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
L
Dog
Lupus familis
XP_534420
1004
115318
Y762
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
Y525
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
P
Rat
Rattus norvegicus
Q9WUL0
767
90741
Y525
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
Y539
T
E
M
D
G
Q
E
Y
V
V
E
F
D
F
L
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
F579
Q
E
L
D
G
Q
E
F
V
V
E
F
D
F
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
N745
K
E
L
N
G
K
E
N
V
V
V
F
D
F
P
Honey Bee
Apis mellifera
XP_396203
973
114099
Y748
E
Q
K
D
G
K
E
Y
V
V
V
F
D
F
L
Nematode Worm
Caenorhab. elegans
O17966
806
94011
F572
D
D
K
K
E
K
E
F
V
V
E
F
D
F
L
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
F637
E
E
Q
D
G
M
E
F
V
V
K
F
D
F
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
S680
F
D
F
L
G
K
D
S
I
Q
Y
V
N
T
V
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
S460
F
D
F
L
G
K
D
S
I
R
F
Y
Q
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
86.6
N.A.
80
N.A.
N.A.
60
66.6
53.3
66.6
P-Site Similarity:
100
13.3
100
100
N.A.
93.3
93.3
N.A.
93.3
N.A.
86.6
N.A.
N.A.
73.3
80
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
22
0
65
0
0
15
0
0
0
0
0
79
0
8
% D
% Glu:
15
65
0
0
8
0
79
0
8
0
58
0
0
8
0
% E
% Phe:
15
0
15
0
0
0
8
22
0
0
8
79
0
79
0
% F
% Gly:
0
0
0
0
86
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% I
% Lys:
8
8
15
8
0
36
0
0
0
0
15
0
0
0
0
% K
% Leu:
0
0
50
22
0
8
0
0
0
0
0
0
0
0
50
% L
% Met:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
8
0
0
0
0
8
0
0
% N
% Pro:
36
0
0
0
0
0
0
0
0
0
0
0
8
0
29
% P
% Gln:
8
8
8
0
8
50
0
0
0
8
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
15
0
8
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
79
79
15
8
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
50
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _